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Biomedical Research

Delivery of Nucleic Acid Therapeutics for Cancer Immunotherapy

Nucleic acid therapeutics have surfaced as hopeful possibilities for cancer treatment, including immunotherapy. The growing number of approved nucleic acid therapeutics by the FDA displays their potential to treat diseases by attacking their genetic blueprints.

By Ilma Khan

Published 6:08 PM EST, Fri June 11, 2021

Introduction

Living in this advanced world today allows us to have access to new incoming ideas such as the use of various drugs that can have great potential and benefit different diseases such as cancer. In this research journal, they focus on the great potential of cancer immunotherapy using various immuno-oncology drugs. The use of nucleic acid therapeutics on different diseases, specifically cancer, has advanced day by day, showing us how different drugs have unique abilities and how these abilities have advanced in the world we live in today. Through trial and error researchers have figured out problems each therapeutic faces, for example, negative charges and hydrophilicity known as the attraction to water. In this research, we learn about the different drug delivery systems that can safely release and target specific cells. Some of the different drugs that can be used to target specific tissues and cells include small interfering RNA (siRNA) and messenger RNA (mRNA). A few of the discussed delivery systems that can safely transport these drugs to the targeted area includes the nanoparticulate drug delivery system of nucleic acid therapeutics using micelle and the delivery of cGAMP using liposomes (structured cGAMP vs. free cGAMP). After the experimenting and research, the results have displayed that these nucleic acid therapeutics have a remarkable amount of potential for a vast assortment of diseases. Each drug has unique skills and characteristics such as changing gene expression and regulating protein function for immune responses but also has challenges blocking the delivery systems to achieve effective transportation to the targeted cells. Each day new delivery systems are created and modifications are made to different therapeutics which would allow us to issue problems connected to the treatment in the immunotherapy of cancer.

General Analysis

Through the process of reading, analyzing, and critiquing this paper many reasons indicate why this paper makes a good contribution to society. The specifics in this paper allows us the readers and writers to dig deep and think. The use of different words we’ve never heard or seen and the use of deep topics that take time to understand makes the readers ask themselves questions and makes them left wanting more, therefore, resulting in researching deeper into the topic. This paper discussed the different nucleic acid therapeutics, the advanced delivery systems of these therapeutics, and the positive functionalities as well as the challenges of these therapeutics allowing the audience to see these therapeutics from all angles so he can add more to the research. Another reason why this paper is a good read is that the paper provides sufficient proof of how science and medicine have advanced together. The paper provides a visual timeline dating back to 1995 when the first description of CpG-dependent stimulation was created. This paper has contributed to the medical society by bringing in new medical knowledge related to different nucleic acid therapeutics and their delivery systems. This paper brought in new medical information by displaying the pros and cons of each drug and the different delivery systems that can be used to target specific diseases. This paper can allow other researchers to conduct experiments on therapeutics and use their information to see which delivery system will work best with the disease they are targeting. This paper presents proof and factual information about what therapeutics have the potential to use towards cancer immunotherapy, leading other researchers into using their research to help towards another experiment. 

Evaluation of Methods Used

The methods utilized in this paper allow for a variety of diseases to be treated, the research was open-ended and shows the potential for each therapeutic and how it can be delivered to target specific tissues and cells. Listing many options for delivery systems and many characteristics for each drug allows other researchers to solve other problems using this research. This research was done on the immunotherapy of cancer using nucleic acid therapeutics meaning it could work on a wide range of cancer types. The researcher’s methods brought proof indicating that these therapeutics could work on the immunotherapy of cancers, they displayed how these drugs can be used and which drugs we should use to be treating this cancer. The treatment of cancer is evolving every day, different medical researchers are looking to find a way to cure cancer and this research could play a big role in finding a sufficient treatment of cancer. As stated in this paper the FDA is starting to approve more studies involving nucleic acids and immunotherapy. Indicating that it will have a significant impact in treating different types of cancers and diseases.

Audience

There are negatives and positives to everything, there are side effects but these effects can also result in something life-changing. This paper provides a variety of information indicating the success of using these therapeutics on cancer immunotherapy but there are still concerns. Concerns regarding the different side effects on the human body after immunotherapy using these drugs, the survival rate, and the possibility of taking all or most of cancer away. Could these therapeutics lead to a new disease in the human body, taking away one cancer resulting in new cancer developing? There may be great proof and progress of using these therapeutics for different diseases but the challenges still exist. Challenges such as could this drug be toxic for the human body, the quantity of this drug vs. how much it costs and as well as what happens to the therapeutics inside my body after the treatment. This paper was published in the right journal for the correct audience that would put interest into this topic. This paper shows how the discovery of nucleic acid therapeutics can work towards advancing medicine and cure a life-threatening disease. 

Problems and Admirations

In this paper, I enjoyed the different points of view on each drug and delivery system. The method used in this paper allows the readers to deeply think about each topic and step on the journey to treating cancer. I admire the researcher’s evaluation techniques as they went in-depth and provided an outstanding amount of information on this topic, hooking the readers causing them to keep reading and researching more about this topic. The researchers brought hope and showed how advances in medicine today can change anyone’s life. After reading this paper I understood the writer’s thought process, I understood all the different ideas they were thinking and it allowed me to feel grateful for the new innovative ideas we have that can save someone’s life. After this paper is published it will show people the future we have that is full of ideas worthy of doing anything. It will allow others to take the little ideas and thoughts in their heads and turn them into something beautiful. This research will contribute to other studies and allow us to be one step closer on the journey to find a cure for cancer. 

Ilma Khan, Youth Medical Journal 2021

References

“Delivery of Nucleic Acid Therapeutics for Cancer Immunotherapy – ScienceDirect.” ScienceDirect.Com | Science, Health and Medical Journals, Full Text Articles and Books., https://www.sciencedirect.com/science/article/pii/S2590098620300105. Accessed 17 May 2021.

By Ilma Khan

Ilma Khan is a junior at The Woodlands College Park High School in The Woodlands, Texas. She is a tennis player who is looking to continue playing in college and enjoys spending time with her friends and family. In her free time, you can find her travelling, playing her guitar, watching greys anatomy and baking! She is interested in the fields of medicine specifically neurology and cardiology and hopes to become a cardiothoracic surgeon in the future!

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